A new approach to microscopic modeling of a hole transfer in heteropolymer DNA
نویسندگان
چکیده
Thermal oscillations of base pairs in the Peyrard-Bishop-Holstein model are simulated by stochastic fluctuations of base overlap integrals. Numerical investigation of the model is carried out for a hole transfer in G1A2G3G4 sequence which was previously studied experimentally by F. Lewis et al. A hole migration between G1 and G3G4 is determined by the matrix elements of the charge transition, but presence and amplitude of their stochastic fluctuations proved to play a key role in reproduction of the experimental kinetics. Good agreement with the experimental data was obtained for a wide range of the model parameters’ combinations.
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